Xianghong   Luan   MD
College of Dentistry
801 S. Paulina Street
  • Xianghong
  • Luan
  • MD
  • Associate Professor
Research Focus:
  • Developmental/Craniofacial Biology
    Periodontal Disease
    Stem Cell Biology

Research Interests

Ameloblastin gene function in extracellular matrices.  Dr. Luan and her colleagues are interested in the role of enamel matrix genes such as ameloblastin in periodontal tissues. They also conduct studies on the role of epithelial cells in periodontal development and maintenance.

Periodontal regeneration.  Dr. Luan and her colleagues are interested in the unique properties of odontogenic stem cells. Currently, they are using stem cell-based concepts in the regeneration of periodontium, pulp, and bone.


  • Advanced Oral Sciences I and II (Graduate Course)
  • Lectures on Periodontal Bioengineering and Craniofacial Embryology of the Head to the Orthodontics Master class
  • Research Mentorship
    • Dr. Xianghong Luan, Recipient of the 2013 UIC COD Mentor of the Year Award
    • Dr. Luan proudly joins her first Ph.D. student, Xuanyu Lu, during his 2014 graduation.   


Function of the Ameloblastin Extracellular Matrix Molecule

Atsawasuwan P., Lu X, Ito, Y., Evans C.A., and Luan X. (2013). Ameloblastin inhibits cranial suture closure by modulating MSX2 expression and proliferation. PLoS ONE 8(4): e52800. doi:10.1371/journal.pone.0052800

Lu X., Ito, Y., Atsawasuwan P., Dangaria S., Evans C.A., and Luan, X. (2013). Ameloblastin modulates osteoclastogenesis through the integrin/ERK pathway. BONE 54, 157-168.

Zhang , Y., Zhang X., Lu X., Atsawasuwan, P., and Luan, X. (2011). Ameloblastin regulates cell attachment and proliferation through RhoA and p27. Eur. J. Oral Sci. 119, 280-285.


Odontogenic Stem Cells and Tissue Regeneration

Pan, S., Dangaria, S.J., Yan, X., Gopinathan, G., Lu, X., Kolokythas, A., Niu, X., and Luan X. (2013). SCF promotes dental pulp progenitor migration, neovascularization, and collagen remodeling – potential applications as a homing factor in pulp regeneration. Stem Cell Reviews and Reports 9, 655-667. 

Li, Q., Pan, S., Dangaria, S.J., Gopinathan G., Kolokythas, A., Chu, S., Geng, Y., Zhou, Y, andLuan, X. (2013). Platelet-rich fibrin (PRF) promotes periodontal regeneration and enhances alveolar bone augmentation. Biomed. Res. Int. http://dx.doi.org/10.1155/2013/638043, 1-13.

Luan, X., Dangaria, S., Ito, Y., Walker, C., Jin, T., Schmidt, M., Galang, T., and Druzinsky, R. (2009). Neural crest lineage segregation: a blueprint for periodontal regeneration. Journal of Dental Research 88, 781-791.


Evolution and Anthropology

Edgcomb, K., BeGole, E., Evans, C., Johnson, B and Luan, X. (2011). Prevalence of short dental roots in four ethnic groups in an orthodontic population. Dent. Anthropol. 24, 11-15.

Luan, X., Walker, C., Dangaria, S., Ito, Y., Druzinsky, R., Jarosius, K., Lesot, H., and Rieppel, O. (2009). The mosasaur tooth attachment apparatus as paradigm for the evolution of the gnathostome periodontium. Evolution and Development 11, 247-259.