Humans discovered through personal experimentation that numerous plants and plant-based products, when placed into the oral cavity, had the capacity to deliver diverse secondary metabolites and thereby elicit a variety of stimulant, medicinal, and hallucinogenic effects.
All historical and world systems of health care advocate plant remedies and/or pharmacognostic derivatives for health and healing. All systems of health care including allopathic/bio-science, Arabic, Ayurveda, Chinese, ethnopharmacology, Judeo-Christian anointing, Native American Indian healing ceremonies, naturopathic, osteopathic, Far-eastern philosophies, and shamanism advocate botanical preparations for the medicinal, mental, and the physical amelioration of pain and disease. Oral and maxillofacial pains, inflammations, and associated pathologies have been documented since the beginning of recorded human history, and the use of plant materials for the relief of these disorders has paralleled this health care need.
Medical anthropology and pharmacognostic research continuously affirms the presence of medicinal compounds in natural products including plants. Contemporary neurobiological and pathophysiologic research has illuminated numerous mechanisms, actions, and mammalian peripheral and CNS receptors responsive to plant-based and other natural compounds. Consequently, theories have emerged that propose a co-evolutionary relationship and functionality between natural products and the various mammalian cell membrane channels, receptors, and tissues.
Our laboratory continues to conduct medical anthropology and ethnopharmacology research associated with plants and other natural products used for oral medicine conditions, pains and pathologies. We leverage classical and portable spectroscopic technologies based on various forms of directed energies (i.e. Raman and FT-IR Spectroscopy) for biometric and pharmacognostic studies.
1. Previously Funded Projects:
"Ethnopharmacological Studies in Oral Medicine." National Institutes of Health (NIH)/National Center for Complementary and Alternative Medicine (NCCAM), K08 Award #AT000987-01.
2. Currently Funded Projects:
"Research, Analysis and Databasing of Emerging High Power Directed Energy Technologies Marketed to the Clinical and Research Communities." Department of Defense (DoD), United States Air Force Surgeon General's Modernization Directorate (USAF/SGR), Cooperative Research Agreement #FA7014-09-2-0003.
Pestle WJ, Brennan V, Sierra RL, Smith EK, Vesper BJ, Cordell GA, Colvard MD. Hand-held Raman spectroscopy as a pre-screening tool for archaeological bone. J Archaeol Sci. 2015 Apr; 58:113-120.
Pestle WJ, Ahmad F, Vesper BJ, Cordell GA, Colvard MD. Ancient bone collagen assessment by hand-held vibrational spectroscopy. J Archaeol Sci. 2014 Feb; 42:381-389.
Budyn E, Bhogle S, Radosevich JA, Colvard MD. Thermal microenvironment of keratinocytes and fibroblasts during cauterization by laser devices. 3rd International Conference on Computational and Mathematical Biomedical Engineering (CMBE2013). Nithiaruasu P, Lohner R (Eds.), Hong Kong, 16-18 Dec 2013. (Conference proceedings)
Vesper BJ, Colvard MD. Photodynamic therapy (PDT): an evolving therapeutic technique in head & neck cancer treatment. In: Head & Neck Cancer: Current Perspectives, Advances, and Challenges. Radosevich JA (Ed.). Springer Science+Business Media: New York, 2013, pp.649-76.
Pestle WJ, Colvard MD. A disease without history? Evidence for the antiquity of head and neck cancers. In: Head & Neck Cancer: Current Perspectives, Advances, and Challenges. Radosevich JA (Ed.). Springer Science+Business Media: New York, 2013, pp.5-36.
Breskey JD, Lacey SE, Vesper BJ, Paradise WA, Radosevich JA, Colvard MD. Photodynamic therapy: occupational hazards and preventative recommendations for clinical administration by healthcare providers. Photomed Laser Surg. 2013; 31(8):398-407.
Cordell GA, Colvard MD. Natural products and traditional medicine: Turning on a paradigm. J Nat Prod. 2012 Mar; 75(3):514-25.
Pestle WJ, Colvard MD. Bone Collagen Preservation in the Tropics: A case study from ancient Puerto Rico. J Archaeol Sci. 2012 Jul; 39(7):2079-90.
Colvard MD, Naiman M, Danzinger, L; Hanley L. Handheld directed energy sensor for environmental monitoring and clinician safety. Aviat Space Environ Med. 2010 Jun; 81(6):602-4.
Colvard MD, Cordell GA. Rationalizing the study of plants for the treatment of oral pain. Curr Chem Biol. 2008 May; 2(2):140-52.
Pestle WJ, Demel S, Colvard MD, Pickering R. Skeletal biology and mortuary practice at the Kubinski Site (11WI1186), a middle woodland ossuary. Ill Archaeol. 2007; 19:47-84.
Cordell GA, Colvard MD. Natural products in a world out-of-balance. Arkivoc. 2007; 2007(7):97-115.
Pestle WJ, Colvard MD, Pettitt P. AMS dating of a recently rediscovered juvenile human mandible from Solutre (Saone-et-Loire, France). Paleo. 2006 Dec; 18:285-92.
Colvard MD, Ashrafi SH, Alonge OK, Cordell GA. Smokeless tobacco-induced lamellar body abnormalities. Oral Dis. 2006 May;12(3):343-8.
Colvard MD, Cordell GA, Villalobos R, Sancho G, Soejarto DD, Pestle WJ, Echeverri TL, Perkowitz KM, Michel J. Survey of medicial ethnobotanicals for dental and oral medicine conditions and pathologies. J Ethnopharmacol. 2006 Aug 11; 107(1):134-42.
Cordell GA, Colvard MD. Some thoughts on the future of ethnopharmacology. J Ethnopharmacol. 2005 Aug 22; 100(1-2):5-14. Review.
Alonge OK, Ashrafi SH, Colvard MD. Mitochondrial volume densities in the smokeless tobacco-treated hamster cheek pouch epithelium. Oral Dis. 2003 May; 9(3):138-43.